The Local Immune Response to Escherichia Coli 0 and K Antigen in Experimental Pyelonephritis
نویسنده
چکیده
response to the 0 antigen of Escherichia coli has been well characterized, little information is available on the immune response to K anigen. Experimental hematogenous pyelonephritis was produced with Escherichia coli 06 K13 HI and the serum and local (intrarenal) antibody response to 0 and K antigens was determined with the enzyme-linked immunosorbent assay. Both local and serum antibody responses to the K antigen were significantly less than that to the 0 antigen. The K antigen induced low titer IgM and IgG antibody responses in fewer than one-half of the animals and did not induce a local IgA response in any animal. In contrast, the 0 antigen induced local antibody responses in each of the immunoglobulin classes in all animals from day 9 of infection. Similarly, the serum IgM and IgG antibody titers to the K antigen were significantly less than those evoked in response to the 0 component of the Escherichia coli. No serum IgA anti-K antibodies were de-
منابع مشابه
The local immune response to Escherichia coli O and K antigen in experimental pyelonephritis.
Although the systemic and local immune response to the O antigen of Escherichia coli has been well characterized, little information is available on the immune response to K anigen. Experimental hematogenous pyelonephritis was produced with Escherichia coli 06 K13 H1 and the serum and local (intrarenal) antibody response to O and K antigens was determined with the enzyme-linked immunosorbent as...
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